Biophysicists Consider Tumor Suppressor Protein 53 To Be A Dimmer Switch

p53 green

p53 (green) is a tumor suppressor

The tumor suppressor protein p53 (green) and its regulator Mdm2 (red) are shown in breast cancer cells using fluorescent tags.

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The tumor suppressor protein p53 (green) and its regulator Mdm2 (red) are shown in breast cancer cells using fluorescent tags. This figure demonstrates that individual cells have different levels of p53 and Mdm2. Time-lapse microscopy revealed that individual cells show multiple pulses of p53 which were masked in previous studies that averaged p53 levels in a population of cells.

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